Synthetic Methods of Organic Chemistry. Volume 13 (Theilheimer, W.)

Synthetic Organic Chemistry

Synthetic biology: lessons from the history of synthetic organic chemistry.

The mid-nineteenth century saw the development of a radical new direction in chemistry: instead of simply analyzing existing molecules, chemists began to synthesize them--including molecules that did not exist in nature. The combination of this new synthetic approach with more traditional analytical approaches revolutionized chemistry, leading to a deep understanding of the fundamental principl...

Half-Century Journey from Synthetic Organic Chemistry to Mathematical Stereochemistry through Chemoinformatics

My half-century journey started from synthetic organic chemistry. During the first stage of my journey, my interest in stereochemistry was initiated through the investigation on the participation of steric effects in reactive intermediates, cylophanes, strained heterocycles, and organic compounds for photography. In chemoinformatics as the next stage of the journey, I proposed the concept of im...

Molecular orbital methods in organic chemistry

Combinatorial Chemistry Online: Volume 13, Issue 10, October 2011

One of the challenges of combinatorial chemistry is the selection of compounds to synthesise. Usually a full combinatorial set will generate large numbers of compounds but at the expense of diversity and in some cases might generate compounds that represent extremes of molecular weight and lipophilicity. Various methods have been employed to improve the quality of library design, and the genera...